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Toll-like receptor 4 and tumor immune escape: Recent progress
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Abstract:
Toll-like receptors (TLRs) is a group of pattern recognition receptors which can sense pathogen invasion; by now 11 TLR members have been identified in the mammalian immune system. Of all these TLRs, TLR4 received the most attention from scientists. TLR4 is expressed in a verity of tumors, and TLR4 activation can promote the development and progression, apoptosis resistance, and invasion and metastasis of tumors. Besides, the exogenous activation and endogenous ligands in tumor microenvironment may also play important roles in tumor immune escape triggered by TLR4. TLR4 is expected to become a new target for cancer biotherapy.
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Project Supported:
Project supported by the National Natural Science Foundation of China （No. 30771984； No.30972688）
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