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Role and possible mechanism of NF-κB in tumorigenesis of prostate cancer
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Abstract:
Prostatitis is a risk factor of prostate cancer. Nuclear factor-κB (NF-κB) plays an important role in the tumorigenesis of prostate cancer induced by prostatitis. Hypoxia, a marker of inflammation, and Toll like receptors both can activate NF-κB. Inflammatory cells can regulate the biological behavior of tumors through NF-κB. Moreover, NF-κB has a cross-talk with many pro-inflammatory factors. NF-κB regulates tumor growth through various ways, including apoptosis promotion and proliferation suppression, mediation of invasion, metastasis and angiogenesis of tumors; NF-κB also can induce progression of prostate cancer from the androgen-dependent to the androgen-independent stage. Anti-inflammation and NF-κB-targeting therapies cast new lights on prostate cancer treatment, which deserves further study.
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Project supported by the National Natural Science Foundation of China (No. 30872591)
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