Mobile website
Review
Bone morphogenetic proteins and prostate carcinoma
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
Prostate carcinoma (PC) is one of the most common male malignancies in Western countries, and recently the morbidity of PC have greatly increased in China. Bone morphogenetic proteins (BMPs) and their receptors (BMPRs) are expressed in prostate and PC tissues. BMPs can induce ectopic bone formation, cell chemotaxis, cell differentiation and embryogenesis. Some BMPs and BMPRs are expressed on PC cells and can be used as the prognostic markers for the development, progression and prognosis of PC. BMPs modulate the biological behaviors of PC cells in a diverse manner, depending on the cell type, cell differentiation state and local microenvironment. BMPs also play important roles in the progression of PC, especially in promoting PC metastasis to bone, accompanied by a strong osteoblastic reaction. Study on the relationship between BMPs and PC can help to explain the development and metastasis of PC, and provide a theoretical basis for PC therapy.
Keywords:
Project Supported:
Clc Number:
