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Expressions of RhoA and Ezrin in breast infiltrating ductal carcinoma and their clinical significances
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Abstract:
Objective : To investigate the expressions of RhoA and Ezrin in breast infiltrating ductal carcinoma (BIDC) and their clinical significances. Methods: Eighty-six BIDC paraffin samples were obtained from Fourth Hospital of Hebei Medical University (Jan. 2008 to Dec. 2008). Immunohistochemical method was used to assess the expression of RhoA and Ezrin in tumor tissues. The relationship between RhoA and Ezrin expressions with the clinicopathological parameters was also analyzed. Results: The expression of RhoA and the strong expression of Ezrin in the 86 BIDC samples were 6047% and 65.12%, respectively, which were both significantly higher than those in normal ductal epithelium groups (all P<0.05). Neither the expression of RhoA nor the strong expression of Ezrin was correlated with patient’s age (P>0.05), and they were positively correlated with the axillary lymph node metastasis, histological grades, and TNM stages (all P<0.05). A significant correlation was also found between the expression of RhoA and the strong expression of Ezrin in BIDC samples (P<0.01). Conclusion: RhoA and Ezrin are highly expressed in IBDC tissues, and may play important roles in the carcinogenesis and progression of BIDC.
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Project Supported:
Project supported by the Natural Science Foundation for Youth Scientists in Hebei Province (No.C2009001212), and the Scientific Foundation for Major Discipline in Higher Institutions of Hebei Province (No.200552), and the Scientific Research Foundation from Health Bureau of Hebei Province (No. 20090487）
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