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MicroRNA and immune regulation: Recent progresses
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Abstract:
MicroRNA (miRNA), an important post-transcriptional regulator, is involved in a variety of physical and pathological processes, including the development of immune cells and inflammation response. Among them, miR-155, miR-17～92, miR-146a, miR-150, and miR-181a are extremely important. MiR-155 is an essential regulator for T and B cell differentiation and antibody class switch of B cells, miR-17～92 is associated with the development of B cells, miR-150 negatively regulates the development of B cells and inflammation response, miR-181a participates in the development of T cells, and miR-146a is a negative regulator of inflammatory response. Further understanding of the regulatory function of miRNA on immune cells and their mechanisms will promote immunology research and its application in the prevention and treatment of immuno-related diseases.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No.30770997, No.30772017, No.30972730), and the Science Foundation from Shanghai Science and Technology Commission (No.08QH14001, No.09JC1405400)
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