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Archive > Volume 17 Issue 6 > 2010,17(6):683-686. DOI:10.3872/j.issn.1007-385X.2010.6.020 Prev Next

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Roles of CXCL12/CXCR4 axis in tumor growth and metastasis and related mechanisms

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    Abstract:
    In recent years, the role of chemokines in tumor growth and metastasis have been attracting greater attention worldwide. Studies on breast cancer, prostate cancer and pancreatic cancer have revealed that CXCL12/CXCR4 axis can increase the growth, inhibit the apoptosis, promote the angiogenesis, affect the targeted metastasis, enhance the adhesion and migration, and regulate the cytokine secretion of tumor cells, which indicates CXCL12/CXCR4 axis may be a new target for antitumor drugs and plays a potential role in clinical tumor therapy.

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    Project Supported:
    Project supported by National Natural Science Foundation of China（No.30872303）

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