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Adoptive cell therapy of cancer-An old story with a new twist
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Abstract:
Adoptive cell therapy (ACT) of cancer has long been proposed, but was gradually forgotten due to its disappointing efficacy. In recent years, great improvement has been made in cancer ACT．ACT with adoptive T cells for immunotherapy of melanoma has achieved impressive outcomes. And CIK（cytokine induced killer cells）has been widely used in clinical treatment of cancers in China, and satisfactory results have been obtained. However, several problems remain to be solved: what kind of cells are suitable for adoptive transfer? How to efficiently induce and screen T cell clones? Whether and how to rapidly amplify T cells through TCR transgenic strategy? How to genetically engineer T cells to improve the efficacy of ACT, and how to properly evaluate the efficacy of ACT, etc.
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Project Supported:
Project supported by the National Science Foundation for Distinguished Young Scholars of China (No.30925037), and the Major Project of Ministry of Science and Technology of China (Special Foundation for Prevention and Treatment of “AIDS and Virus Hepatitis” Major Infectious Diseases) (No. 2008ZX10002-023)
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