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Relationship between Treg and Th17 cells in peripheral blood of acute leukemia patients
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Abstract:
Objective : To observe the proportions of CD3+CD4+TIL-17+ helper T cells (Th17 cells) and CD4+TCD25+Foxp3+ regulatory T cells (Tregs) in the peripheral blood of acute leukemia patients and the changes of related cytokines (including IL-17, TGF-β, IL-6), and to analyze their relationship. Methods: The ratios of Treg and Th17 cells in peripheral CD4+T cells were examined by flow cytometry. The serum levels of IL-17, TGF-β and IL-6 were measured by ELISA. Results: The ratio of Th17 cells in CD4+T cells was (1.39±0.24)%, which was significantly higher than that in the control group (\[0.26±0.11\]%, P<0.05); the ratio of Treg cells in CD4+T cells was (11.58±217)%, which was significantly higher than that in the control group (\[2.47±0.72\]%, P<0.05); and Treg cells were positively related with Th17 cells. The serum levels of TGF-β, IL-6, and IL-17 in acute leukemia patients were (26.06±243), (14.66±2.47), and (18.63±2.38) pg/ml, respectively, which were significantly higher than those in the control group (\[13.41±1.92\],\[1.44±0.29\], and \[10.34±1.71\] pg/ml, P<0.05). Conclusion: The ratios of Treg and Th17 cells are increased in the peripheral blood of acute leukemia patients, and they are positively correlated with each other. The serum levels of TGF-β, IL-6, and IL-17 are also elevated, which may affect the balance between Treg cells and Th17 cells.
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Project Supported:
Project supported by the Science and Technology Supporting Program of Gansu Province (No.0804NKCA115)
Clc Number:
