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Genetic engineering antibody fragments-A novel tune for the antibody family
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Abstract:
With the advances in molecular biology and the clarification of antibody genetic structure, a variety of smallmolecule antibody basedand genetic manipulatedgenetic engineering antibody fragments have emerged and been widely used in scientific research, clinical diagnosis and therapy. Among which, bispecific antibody with combined biological activity and therapeutic targeting activity, immunoconjugate with enhanced function and targeting cytotoxicity, nanobody with special single domain structure which is widely applied in biological technology and clinical research, and intrabody with special intracellular expression are the most active fields in antibody fragment research. Genetic engineering antibody fragments have received extensive attention and approval over fulllength monoclonal antibodies owing to their desirable characteristics, such as weak immunogenicity, strong tissue permeability, minimal toxicity and simple preparation. although the safety and efficiency of most antibody fragments in clinical research still need to be further identified, development of scientific research on genetic engineering antibody fragments, will inevitably improve diagnosis and therapy of human diseases.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No. 30872750)
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