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Expressions of KISS1 and osteopontin in epithelial ovarian cancer and their clinical significance
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Abstract:
Objective : To investigate the expression and clinical significance of KiSS-1 metastasis-suppressor (KISS1) and osteopontin (OPN) in epithelial ovarian cancer (EOC). Methods: From March 2009 to October 2010, epithelial ovarian tumors of 67 patients operated in Gynecology Department of the Fourth Hospital of Hebei Medical University were selected. The expressions of KISS1 and OPN in EOC were detected by immunohistochemistry (IHC). Results: The frequency of KISS1 positive expression was 39.53% (17/43) in EOC tissues, which was significantly lower than that in ovarian benign tumor tissues (75.00%, 18/24), with a significant difference between two groups (χ 2=7.765, P=0005). The expression of KISS1 protein in the lymph node metastasis group was significantly lower than that in the without lymph node metastasis group (250% \[7/28\] vs 66.7% \[10/15\]; χ 2=7.094, P=0.008). In the clinical stage group, the expression of KISS1 protein was significantly higher in Ⅰ+Ⅱ stage than in Ⅲ+Ⅳ stage (61.1% \[11/18\] vs 24.0% \[6/25\]; χ 2=6.029, P=0.014). The frequency of OPN positive expression was 74.42% (32/43) in EOC tissues, which was significantly higher than that in the ovarian benign tumor tissue group (37.50%, 11/24) with a significant difference between two groups（74.4% \[32/43\] vs 37.5%\[11/24\];χ 2=5.475, P=0.019）. The expression of OPN in the lymph node metastasis group was significantly higher than that in the without lymph node metastasis group (893% \[25/28\] vs 46.7% \[7/15\]; χ2=7.251, P=0.007). In the clinical stage group, the expression of OPN was significantly lower in Ⅰ+Ⅱ stage than in Ⅲ+Ⅳ stage (50.0% \[9/18\] vs 92.0 \[23/25\]; χ 2=7.616, P=0.006). The protein expressions of KISS1 and OPN were not correlated with pathologic classification and patient’s age of EOC （ P＞005 ）, and there was a negative correlation between KISS1 and OPN protein expressions (r=-0.507, P=0001). Conclusion: The protein expressions of OPN and KISS1 may participate in the carcinogenesis, invasion and metastasis of EOC, which may contribute to prognosis marker of EOC.
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Project Supported:
Project supported by the Medical Research Projects of Health Bureau of Hebei Province (No. 05013)
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