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Clinical Research
Adjuvant treatment with interferon for patients with hepatocellular carcinoma: A Meta analysis based on randomized controlled trials
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Abstract:
Objective : To quantitatively assess the efficacy of interferon (IFN) in the adjuvant treatment for patients with hepatocellular carcinoma (HCC) using Meta analysis. Methods: Randomized controlled trials (RCTs) of adjuvant treatment with interferon for patients with HCC were searched in Embase, Medline, Cochrane Library, Chinese biomedicine literature database, Chinese Scientific Journals full-text database, and Chinese Journal full-text databases. Two reviewers independently assessed the quality of included studies and extracted data. Meta analysis was carried out using Review Manager (version 5.0) provided by Cochrane Collaboration. Results: Eight RCTs totaling 836 patients were included. Meta analysis showed that the adjuvant treatment with IFN significantly reduced the recurrence rate after curative treatment of HCC, with a pooled risk ratio of 0.86 (95 percent confidence interval 0.77 to 0.96); the effect on reduction in mortality rate was still significant with a pooled risk ratio of 0.64 (95 percent confidence interval 0.54 to 0.76). Conclusion: IFN has a beneficial effect on both mortality rate and tumour recurrence, and the results still need to be confirmed by RCTs of high quality and large sample size.
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