Mobile website
Young Scholar Forum
Cancer-associated CD8+ memory T cells in the application of adoptive immunotherapy
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
In the research area of clinical cancer therapy, the adoptive immunotherapy has been a hot topic. There are natural anticancer CD8+ memory T cells existing in the patient body, which can actively recognize, target and kill cancer cells. These T cells respond rapidly to only a small number of cancer cells re-circulating in the body and act as a long-term cancer surveillance force there. Bone marrow is the major place where the anticancer CD8+ memory T cells reside. If isolated, primed and expanded properly, bone marrow-derived anticancer CD8+ memory T cells can exhibit a giant power in the adoptive immunotherapy. In order to give clinical researchers a clear picture of the biological characteristics and therapeutic values of anticancer CD8+ memory T cells as well as to help them deal with the problems encountered in the clinical application, we reviewed recent research progressions on the application of anticancer CD8+ memory T cells in the cancer immunotherapy
Keywords:
Project Supported:
Project supported by the National Natural Science Foundation of China (No. 30801363), and the Foundation of Shanghai Municipal Education Commission (No. 08YZ43)
Clc Number:
