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Association between infection of hepatitis B virus and onset risk of non-Hodgkin lymphoma: A Meta analysis
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Abstract:
Objective:To systematically evaluate the association between hepatitis B virus (HBV) infection and non-Hodgkin lymphoma (NHL). Methods: Case-control studies on the association of HBV infection with NHL were collected from Medline, EMBASE, PubMed, the Cochrane Library, Chinese Biomedical Literature Database, Chinese Scientific Journal Full-text Database, and Chinese Journal Full-text Database. The data extraction and Meta-analysis (STATA 110) was performed by two reviewers independently. Results: 15 case-control studies and 8 nested case-control studies were included in the present study. The Meta results showed that odd radio (OR) of HBV infection in NHL when compared with the control population was 2.44 (95% CI, 2.25-2.63) in the fixed effect model and 2.49 (95% CI, 1.95-3.18) in the random effect model. There was evidence of statistical heterogeneity in all included studies (I2=86.8%，P<0.05), which disappeared in the subgroup nested case-control studies (I2=15.9%，P>0.05). OR was 2.49 (95% CI, 1.95-3.18) in the random effect model, suggesting a higher prevalence of HBV carrier state in NHL than controls. Conclusion: There is a possible causal relation between HBV infection and NHL, which needs to be confirmed by experimental and epidemiological studies.
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