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Expressions of CXCR4 and CD40 in human cervical carcinoma and their correlation with myometrial invasion
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Abstract:
Objective: To assess the expressions of CXC chemokine receptor 4 (CXCR4) and CD40 in human cervical carcinoma tissues and evaluate the correlation between their combined expression and the depth of the myometrial invasion. Methods: Fifty-three patients with cervical carcinoma aged of 29-53 years (median 41) from the First Affiliated Hospital of Soochow University were included in this study (2009-2011). The expressions of CXCR4 and CD40 in 53 cases of cervical carcinoma tissues were detected by immunohistochemistry. Then the association between the expressions of these two proteins and the depth of myometrial invasion was analyzed. Results: CXCR4 and CD40 were found to be expressed in cervical carcinoma tissues at different levels, and there was a positive correlation between CD40 and CXCR4 expressions (P=0.035). Of 22 cases which highly expressed CXCR4, 11 were found with a high expression of CD40. Furthermore, combined analysis of CXCR4 and CD40 expressions made results more relevant to the myometrial invasion. The depth of myometrial invasion was significantly higher in patients (90%) with a high expression of both CXCR4 and CD40 than in those (72%) with a high expression of one of the molecules, or those (20%) without high expressions of these two molecules (P<0.05). Conclusion: The expressions of CXCR4 and CD40 in cervical carcinoma tissues are correlated with the depth of the myometrial invasion.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No. 81101556), and the Research Innovation Project for University Graduate Student in Jiangsu Province (No.CXZZ11_0110); Suzhou Science and Technology Development Project (No. YSD2011084)
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