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Expressions of RECK and MMP-9 in endometrial carcinoma and their clinical significance
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Abstract:
Objective: To investigate the expressions of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) mRNA and matrix metalloproteinase-9 (MMP-9) mRNA in endometrial carcinoma and explore their clinical significance. Methods: Forty-two endometrial carcinoma samples were obtained from gynecological surgery in the Affiliated Hospital of Binzhou Medical University (Mar. 2009 to Dec. 2010). Real-time quantitative PCR was used to assess the expressions of RECK and MMP-9 mRNA in endometrial carcinoma, and their relationship with clinic pathological features of endometrial carcinoma was analyzed. Results: The expression level of RECK mRNA was progressively decreased from the normal to invasive carcinoma (\[6.30±0.34\], \[4.29±0.36\], \[0.24±0.18\]，F=427.35, P<0.05）, while MMP-9 mRNA progressively increased (\[0.08±0.82\], \[5.04±0.30\], \[6.22±0.32\]，F=1117. 52, P<0.05). Both expressions of RECK and MMP-9 mRNA were correlated with TNM stage, histological grade and lymph node metastasis of endometrial carcinoma (P<0.05). There existed a significantly negative correlation between the expressions of RECK mRNA and MMP-9 mRNA in endometrial carcinoma (r=-0.832, P<0.01). Conclusion: Combined detection of RECK mRNA and MMP-9 mRNA by quantitative PCR has a certain value for predicting risk of early diagnosis of endometrial carcinoma and recancerous lesions.
Keywords:
endometrial carcinoma ; reversion-inducing cysteine-rich protein with Kazal motifs ; matrix metalloproteinase-9 ; real-time quantitative PCR
Project Supported:
Project supported by the Shandong Province Health Care Medicine Research Foundation (No. 2007BZ20)
