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Tumor immunotherapy targeting cancer stem cells
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Abstract:
Cancer stem cells (CSCs) with self-renewal, proliferation and defective differentiation capacities are the seeds leading to tumor occurrence and metastasis. Due to chemo-resistance, radio-resistance and immuno-resistance, CSC is responsible for tumor relapse. It is pivotal to eliminate CSC so as to improve outcome of tumor therapy. Recognizing surface biomarkers and stemness-related essential molecules of CSC is favorable for attacking CSC efficiently and distinctively. Immunotherapy with characteristics of tumor antigen recognition and spatial and temporal dependent reactive effects lays the foundation of targeting CSC. It is practical and challenging to eliminate CSC through immunotherapy mainly relying on monoclonal antibody and sensitized-immune cells.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No.30973454)
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