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Clinical Research
Expression of tyrosine protein kinase in hepatic cancer tissues and its relationship with prognosis of hepatic cancer patients
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Abstract:
Objective : To study the clinicopathological significance of the expressions of ERK, C-Jun and JAK2 in hepatic cancer tissues and adjacent tumor tissues. Methods: The expressions of ERK, C-Jun and JAK2 in 60 hepatic cancer specimens and adjacent tumor tissues (from Department of Gastroenterology, Affiliated Hospital of Medical College of Chinese People’s Armed Police Forces) were detected by immunohistochemical SP method. A Cox multivariate analysis was performed in those patients to study the factors that influence the prognosis of hepatic cancer. Results: The average values of ERK, C-Jun and JAK2 in hepatic cancer tissues were significantly higher than that in the tumor-adjacent tissues (\[0.23±0.03\], \[0.18±0.06\], \[0.19±0.07\] vs \[0.16±0.02\], \[0.13±0.02\], \[0.14±0.05\], P<0.01). The univariate analysis results showed that the major significant prognostic factors influencing survival was the expression of C-Jun and JAK2 (P<005), and multivariate analysis revealed that the expression of JAK2 was the most important prognostic factor for hepatic cancer (P<0.05). Conclusion: The expression of JAK2 may be an prognostic factor for hepatic cancer patients.
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Project Supported:
Project supported by the Start-up Foundation of Chinese People’s Armed Police Forces (No. WBS200814)
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