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Expressions of P110α and pAKT proteins in esophageal carcinoma tissues and their clinical significance
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Abstract:
Objective : To explore the relationship between the expression levels of P110α and pAKT in esophageal carcinoma (EC) tissues with clinical features of EC. Methods: EC tissues from 76 patients and esophageal tissues from 25 normal controls were collected from the Department of Pathology, No. 101 Hospital of PLA during May 2010 to May 2011. The expression levels of P110α and pAKT in EC and normal esophageal tissues were detected by SP immunohistochemistry. Results: The positive rates of pAKT and P110α in the EC group were 72.4% (55/76) and 57.9% (44/76), respectively, which were significantly higher than those in the control group（PpAKT=0.001，PP110α=0025）. The high level of protein expressions of pAKT and P110α were correlated with lymph node metastasis of EC（PpAKT=0.017，PP110α=0009). However, no correlation was found with other clinical pathological features. The double positive rate of pAKT and P110α expression in EC was 52.6% (40/76). The expression of pAKT was found in a positive correlation with P110α(r=0.486，P=0.001). Conclusion: P110α and pAKT expressions in EC are correlated with lymph node metastasis, and P110α and pAKT might be used as markers of lymph node metastasis in EC.
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Project Supported:
Project supported by the “Six Talent Peaks” Project of Jiangsu Province （No. 200967）
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