Mobile website
Basic Research
Function of vasculogenic mimicry in tumor angiogenesis of osteosarcoma in nude rats and mice
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
Objective:To investigate the structure characteristics and roles of vasculogenic mimicry in the xenografts of human osteosarcoma cells in nude mice. Methods: The models of xenografts of MG-63 human osteosarcoma cells in nude mice and xenografts of UMR106 osteosarcoma cells in nude rats were constructed. The construction features of vasculogenic mimicry and their relationship with tumor microvascular in transplanted osteosarcoma were observed by CD34 and CD147 immunofluorescence staining and GFP staining. Results:CD147 was positive for MG-63-cell-transplanted osteosarcoma tissues and CD34 wsa positive for vascular endothelial cells. The construction of vasculogenic mimicry was observed in the central area of transplanted osteosarcoma, which was constituted mainly by osteosarcoma cells and had the function of the blood vessel. The construction of tumor microvascular was observed in the surrounding area of transplanted osteosarcoma, which was constituted mainly by vascular endothelial cells and connected to vasculogenic mimicry by certain pipeline sample structure. Conclusion:Vasculogenic mimicry in osteosarcoma tissues functions as the blood vessels and can be connected to tumor microvascular so that they can induce tumor microvascular infiltrating into internal tumors.
Keywords:
Project Supported:
Project supported by the National Natural Science Foundation of China (No. 30471760)
Clc Number:
