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Expression of glutathione S-transferase in colorectal mucinous adenocarcinoma and its clinical significance
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Abstract:
Objective: To study the expression of glutathione S-transferase (GST) in colorectal mucinous adenocarcinoma (MC) and non-mucinous adenocarcinoma (non-MC) and analyze its clinical significance. Methods: The expressions of GST, nm23 and cytokeratin 7 (CK7) in 109 MC and 441 non-MC specimens (from Colorectal Surgery Department, Xinhua Hospital Affiliated to Shanghai Jiaotong University) were detected by using an immunohistochemical method to explore the clinical significance. Results: The positive rates of GST and nm23 in the MC tissues were 52.3% and 57.8% respectively, which were significantly lower than those in the non-MC tissues (64.7%, 73.0%; P<0.05); while the positive rate of CK7 in the MC tissues was 27.5%, which was significantly higher than that in the non-MC tissues (18.4%, P=0.033). The expression of GST was correlated with differentiation and lymph node metastasis of MC; however, no correlation was found between the expressions of CK7 and nm23 and clinical pathological features of MC. Conclusion: GST is abnormally expressed in MC and non-MC tissues, and GST expression might be used as a biomarker of differentiation and lymph node metastasis in MC.
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Project Supported:
Project supported by the Science and Technology Foundation of School of Medicine of Shanghai Jiaotong University（No. YZ1038）
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