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Archive > Volume 20 Issue 3 > 2013,20(3):259-265. DOI:10.3872/j.issn.1007-385X.2013.03.001 Prev Next
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Inflammation: A promoter in malignant progression of tumor
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Abstract:
Increasing evidence indicated that tumor inflammatory microenviroment plays an important role in cancer initiation and development. The signaling pathways mediated by inflammatory cytokines participate in malignant transformation of tumor cells. Epithelial-mesenchymal transition (EMT) is a critical mechanism underlying transformation of tumor cells. A network composed by inflammatory cytokines (interleukin, TNF-α and TGF-β), key transcription factors of EMT, including zinc finger E-box-binding homeobox (ZEB), Snail and Twist, and some miRNAs (let-7 and miR-200) regulates malignant transformation of tumor, generation of drug resistance and the proliferation and the self-renewal of cancer stem cell (CSC). This article reviews the recent studies on the molecular mechanisms, by which inflammation and related signaling pathways regulate tumor initiation, development and CSC formation.
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Project Supported:
Project supported by the National Key Basic Research Development Program (973 Program) of China (No. 2010CB911904), and the National Natural Science Foundation of China (No. 31271440, No. 81272232, No. 30972690)
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