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Archive > Volume 20 Issue 3 > 2013,20(3):323-329. DOI:10.3872/j.issn.1007-385X.2013.03.012 Prev Next
Clinical Research
Expression of ubiquitin-conjugating enzyme H10 in meningioma tissues and its clinical significance
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Abstract:
Objective:To investigate the expression of ubiquitin-conjugating enzyme H10 (UbcH10) protein in meningiomas tissues of different pathological grades and its clinical significance. 〖WTHZ〗Methods：〖WTBZ〗Forty-seven patients diagnosed as meningioma with integrity clinical and follow-up information during April 2002 to September 2009 were selected from Department of Neurosurgery, Changzheng Hospital and were graded according to the 2007 WHO standard. The expressions of UbcH10 and Ki-67 proteins in meningioma tissues of various pathological grades were examined by immunohistochemistry. The correlation between the expressions of UbcH10 and Ki-67 protein was analyzed by using Spearman method. The correlation of UbcH10 expression with meningioma recurrence-free surivival was analyzed using the Kaplan-Meier method. 〖WTHZ〗Results：〖WTBZ〗UbcH10 protein was mainly expressed in the cytoplasm of meningioma cells. The expression of UbcH10 protein in meningioma tissues was significantly higher than that in normal brain tissues (\[5.57±1.72\]% vs 0，P=0.00). Quantitative analysis confirmed that the expression of UbcH10 protein was significantly higher in atypical and anaplastic meningiomas as compared with classic meningiomas (\[10.53±5.79\]% vs \[4.23±2.85\]%, P<0.01), indicating that the expression of UbcH10 protein was correlated with meningioma pathological grade and recurrence. The expression of UbcH10 protein was correlated with the expression of Ki-67 protein (r=0.77, P<0.01). Kaplan-Meier survival curve result indicated patients with high expression level of UbcH10 and Ki-67 and higher pathological grade showed a significantly shortened recurrence-free surivival than those with a lower expression level of UbcH10 (P=0.007) and Ki-67 (P=0.018), and a lower pathological grade (P<0.01). Cox multivariate regression analysis showed that the pathological grade (P=0.029) and the expression level of UbcH10 (P=0.044) were independent prognosis factors for meningioma patients, with the hazard ratio of 2.918 and 4756, respectively. Whereas, the clinicopathological factors, including age, gender, Ki-67 level, tumor diameter and tumor location were not independent factors for prognosis. Conclusion:UbcH10 may be involved in the development and progression of meningioma, and UbcH10 expression is an independent risk factor that could predict the prognosis.
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Project Supported:
Project supported by the Scientific Foundation of Science and Techology Committee of Shanghai (No. 08431900400)
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