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Archive > Volume 20 Issue 4 > 2013,20(4):456-460. DOI:10.3872/j.issn.1007-385X.2013.04.013 Prev Next
Clinical Research
Expression of EGR-1 protein in human lung squamous cell carcinoma tissues and its clinical significance
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Abstract:
Objective: To detect the expression level of early growth response gene-1 (EGR-1) protein in human lung squamous cell carcinoma tissues, and to investigate the relationship of EGR-1 protein expression with clinicopathologic factors and prognosis of lung squamous cell carcinoma. Methods: Carcinoma and corresponding paracancerous tissues were obtained from 83 lung squamous cell carcinoma patients (Qilu Hospital of Shandong University during Jan. 2007 to Dec. 2007). Immunohistochemical staining (SP method) was performed to detect the expression level of EGR-1 in carcinoma and paracancerous tissues. χ2 test was used to analyze the relationship between EGR-1 protein expression and patients' clinicopathologic factors, Kaplan-Meier method was used to calculate the 5-year survival rate of patients, Log-rank test was used to compare survival differences, and Cox regression analysis was used to determine the independent prognostic factor. Results: The expression of EGR-1 protein in lung squamous cell carcinoma tissues was significantly lower than that in paracancerous tissues (\[4.12±0.35\] vs \[6.90±4.58\], P<0.01). EGR-1 protein low expression was not significantly associated with patient’s age (P=0.912) and gender (P=0.429), and the differentiation stage of tumor (P=0.289), but significantly associated with patient’s smoking history (P=0.025), tumor size (P=0.013), lymph node metastasis (P=0.003) and TNM stage of tumor (P=0.028). The patients with a low expression of EGR-1 protein had a significantly low overall survival (2.5% vs 15.9%, P=0.04) at 5 years after operation compared with patients with a high expression of EGR-1 protein. TNM stage (P=0.020) and low expression of EGR-1 protein (P=0.035) were independent prognosticators of patients with lung squamous cell carcinoma. Conclusion: EGR-1 protein is low expressed in lung squamous cell carcinoma tissues, and is associated with tumor progression and prognosis.
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Project Supported:
Project supported by the National Natural Science Foundation of China （No．30571844）
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