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Archive > Volume 20 Issue 4 > 2013,20(4):468-474. DOI:10.3872/j.issn.1007-385X.2013.04.015 Prev Next
Clinical Research
A Meta-analysis of Kang’ai injection combined with chemotherapy in the treatment of gastric cancer
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Abstract:
Objective: To investigate whether Kang’ai injection combined with chemotherapy can improve the clinical efficiency of patients with gastric cancer treated with chemotherapy alone. Methods: Relevant randomized controlled trials (RCTs) of Kang’ai injection combined with chemotherapy on gastric cancer patients were searched in the PubMed, CJFD database, VIP database and CBMdisc database published in 2005-2012. Stata software was used for data processing and Meta analysis. Results: Fourteen RCTs were included in the Meta analysis. Meta analysis results suggested that compared with chemotherapy alone, the combination therapy containing Kang’ai injection significantly improved the quality of life (QOL) (P=0.000), white blood cell (WBC) reduction (P=0.000), gastrointestinal reaction (P=0.000), liver injury (P=0.047), peripheral neuritis (P=0.000), weight lose (P=0.002) and pain (P=0.017) of patients with gastric cancer. However, the Kang’ai injection combined with chemotherapy showed no significant difference on clinical efficiency (P=0.093) and other side effects compared with chemotherapy alone. Conclusion: From the existing clinical evidence, Kang’ai injection combined with chemotherapy can improve the life quality of patients with gastric cancer and alleviate some common side effects of chemotherapy.
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Project Supported:
Project supported by the Natural Science Foundation of Shandong Province (No. ZR2010HM059)
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