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Archive > Volume 20 Issue 5 > 2013,20(5):597-602. DOI:10.3872/j.issn.1007-385X.2013.05.016 Prev Next
Clinical Research
Expressions of MAGE-A4 and P73 protein in breast cancer tissues and their clinical significance
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Abstract:
Objective : To investigate the expressions of melanoma-associated antigen (MAGE)-A4 and tumor suppressor gene P73 in breast cancer tissues and paracancerous tissues and their clinical significance. Methods: Sixty patients with breast cancer from September 2007 to December 2007 in Fourth Hospital of Hebei Medical University were enrolled in the study. The expressions of MAGE-A4 and P73 proteins in breast cancer tissues and paracancerous tissues were detected by immunohistochemisty assay, and their correlations with the clinicopathological features of breast cancer were analyzed. Results: The positive expression rates of MAGE-A4 and P73 in breast cancer tissues were 63.3% (38/60) and 43.3% (26/60), respectively, while in adjacent tumor tissues were 0 (0/60) and 85% (51/60), respectively (P<001). In the breast cancer tissues, the expression of MAGE-A4 protein was positively correlated with P73 (r=0.316, P=0.014). MAGE-A4 protein expression was not correlated with patients’ age, pathological type, histological grade, clinical stage, tumor size, metastatic state of lymph node, estrogen receptor (ER), as well as progestrogen receptor (PR) status. However, MAGE-A4 protein expression was negatively correlated with expression of C-erbB2 protein (r=-0.259, P=0046). P73 protein expression was not correlated with patients’ age, pathological type, histological grade, clinical stage, tumor size, metastatic state of lymph node, and C-erbB2 expression. Whereas, the expression of P73 protein was positively correlated with the expression of ER (r=0.274, P=0.034) and PR (r=0.262, P=0.043). Conclusion: Breast cancer tissues highly express MAGE-A4 and P73 protein, and there exists an important regulatory mechanism between MAGE-A4 and P73 protein.
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Project supported by the Natural Science Foundation of Hebei Province (No. H2012206077)
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