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Archive > Volume 21 Issue 3 > 2014,21(3):320-324. DOI:10.3872/j.issn.1007-385X.2014.03.015 Prev Next
Clinical Research
Expression and clinical significance of Livin and Caspase-7 protein in human osteosarcoma tissues
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Abstract:
The aim of this study was to analyse livin and caspase-7 expression at the protein level in correlation with the clinical diagnosis, treatment and prognosis of osteosarcoma. Method: Paraffin-embedded 51 osteosarcoma and 12 normal bone tissue specimens were prepared by the Orthopedics Department of our hospital between February 2001 and December 2012. Livin and caspase-7 proteins in the specimens were assessed by immunohistochemical staining. The correlations of livin and caspase-7 protein levels with the clinicopathological features and prognosis of osteosarcoma were analyzed. Results: Compared with normal bone tissue, Osteosarcoma tissue had a significantly higher percentage of livin-positive cells (66.7% vs 8.3%, P<0.01) but a significantly lower percentage of caspase-7-positive cells (49.0% vs 100.0%, P<0.01), as compared with the normal bone tissue. The proportions of livin- and caspase-7-positive cells were significantly correlated with tumor size, Enneking stage and the 5-year survival rate (P<0.01), but was independent of age, gender, pathological type and tumor site (P>0.05). The expression of livin was negatively correlated with the expression of caspase-7 (r=-0.305, P=0.029). Conclusion: Livin expression is positively correlated but caspase-7 expression is negatively correlated with the severity and prognosis of osteosarcoma , suggest that these two proteins may potential diagnostic and prognostic significance for osteosarcoma.
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Project Supported:
Project supported by Science and Technology of Jiangxi Province (No.00160631121206025)
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