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Relationship between estrogen receptor-1 gene single nucleotide polymorphism and genetic susceptibility in 21 hepatocellular carcinoma families pedigrees of Zhuang population in Fusui County of Guangxi
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Abstract:
Objective : To investigate the relationship between estrogen receptor 1 gene ( ER-1 ) single nucleotide polymorphism(SNP) and susceptibility to hepatocellular carcinoma (HCC) in liver cancer family pedigrees of Zhuang population in Fusui county of Guangxi. Methods: This was a case-control study involving 85 members of 21 HCC high incidence families and 39 members of 10 normal control families in Fusui County, Guangxi Province. Genotype frequencies and restriction fragment length polymorphisms of the ER-1 gene were determined by PCR. Correlation between the ER-1 gene polymorphisms and HCC risk was evaluated by non-conditional logistic regression analysis. Results: The frequencies of genotypes AA, AG, GG among the normal controls and HCC high incidence families was 74.36 vs 83.53%, 17.95 vs 11.76%, and 7 69 vs 4.71%, respectively. Age and sex distributions did not differ significantly between the two groups ( P >0.05) and genotype distributions conformed to Hardy-Weinberg equilibrium. In the normal control families, the risk of HCC for members with AG and GG was 0.218 (95% CI =0.025-1.917, P =0.170) and 0.509 (95% CI =0.049-5.260, P =0.571) times that of members with AA respectively. In the high HCC incidence families, the risk of HCC for members with AG and GG was respectively 0.298 (95% CI =0.035-2.515, P =0.266) and 0.671 (95% CI =0070-6391, P =0.729) times that of members with AA. Conclusion: There is no correlation between ESR1 gene rs3798757 polymorphism and susceptibility to HCC in families with high incidence of liver cancer in Fusui County of Guangxi Province.
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Project Supported:
Project supported by the National Natural Science Foundation of China（No. 81260320）
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