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Clinical Research
Golgi phosphoprotein 3 expression in non-small cell lung cancer and its clinical significance
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Abstract:
Objective : To investigate the possible involvement of Golgi phosphoprotein 3 (GOLPH3) in the development and progression of non-small cell lung cancer (NSCLC) by examining the expression of GOLPH3 in cancerous versus noncancerous lung tissue. Methods: Cancerous ( n =116) and para-carcinoma ( n =43, at least 5 cm from the tumor proper) lung tissue specimens were collected from 116 patients with NSCLC who were surgically treated between February, 2004 and February, 2006 in Qilu Hospital of Shandong University． GOLPH3 protein in these specimens was assessed by immunohistochemistry. Possible correlations of the intensity of the immunoreactive GOLPH3 protein signal were various clinical and pathologic variables were analyzed by Cox regression analysis. Results: GOLPH3 protein was detected in 57 8% (67/116) of the cancerous specimens and in 28.0% (12/43) of the non-cancerous specimens ( P ＜0.01). The intensity of the immunoreactive GOLPH3 protein signal was not significantly correlated with any of the clinical and pathological variables assessed ( P >0.05). In addition, univariate and multivariate analysis demonstrated that BRF2 protein overexpression were significantly associated with tumor relapse and prognosis. Conclusion: GOLPH3 is present in a robustly higher rate in cancerous tissue than in non-cancerous lung tissue of patients with NSCLS. The diagnostic and prognostic value of GOLPH3 for NSCLS warrants further investigations.
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Project Supported:
Project supported by the National Natural Science Foundation of China（No. 30571844）, the Natural Science Foundation of Shandong Province（No. ZR2013HM089），and the Wu Jie Ping Medical Foundation （No. 320.6750.12393）
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