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LYRIC in hepatocellular carcinoma: Expression and potential prognostic significance
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Abstract:
Objective : To determine the expression profile of lysine-rich CEACAM1 coisolated (LYRIC) in hepatocellular carcinoma (HCC) and matched adjacent normal liver tissue. Methods: Matched biopsy specimens of the tumor proper and the corresponding adjacent normal mucosa were collected from 87 HCC patients who underwent surgical resection in China Medical University-Affiliated Shengjing Hospital and General Hospital of Shenyang Military Region. LYRIC mRNA and protein in these specimens were assessed by realtime PCR and immunohistochemical staining. The potential significance of LYRIC mRNA and protein level measurements in the prognosis of HCC were evaluated by multivariate analysis. Results: In 56 (64.7%) of the 87 matched specimens, LYRIC mRNA was significantly higher in HCC than in the adjacent mucosa. LYRIC protein was detected in both HCC and adjacent normal tissue in all 87 cases, but the level was significantly higher ( P <0.001) in HCC (2.16±0.87) than in adjacent normal tissue (1.63±0.88). Enhanced LYRIC expression was associated with poor prognosis (Log-rank10.236， P =0.001). Metastasis (HR=2.44), elevated LYRIC expression (HR=2.19) in HCC and tumor stage(HR=2.01) were independent risk factors of overall survival. In contrast, overall survival was not associated with tumor diameters and virus infection. Conclusion: LYRIC expression is significantly up-regulated in HCC as compared with normal liver tissue. Both LYRIC mRNA and protein levels in HCC are closely associated with the molecular subtype and staging of the tumor, prognosis, suggesting that LYRIC may serve as a potential prognostic factor of liver cancer.
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Project supported by the Grants from the National Research Key Project of the Twelfth Five-Year Plan of the Bureau of Science and Technology (No. 2012ZX09303016-002), and the Science and Technology Key Programs of Liaoning Province (No.2012225019)
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