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Expression and clinical significance of ezrin and CD44 in renal cell carcinoma
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Abstract:
Objective:The aim of this study was to analyze the expression at the protein level and clinic significance of ezrin and CD44 in renal cell carcinoma (RCC). Methods: Paraffin sections were prepared from renal cell carcinoma ( n =56 ) and adjacent tissue ( n =17) specimens collected from 56 RCC patients who were admitted to the Urology Department, Hunan Cancer Hospital between February 2012 and November 2012. Ezrin and CD44 proteins in these sections were assessed immunohistochemical staining. The correlation of ezrin and CD44 protein levels with the clinicopathological features of carcinoma lesions were analyzed. Results: Ezrin was detected in 60.7% (34/56) of RCC tissue specimens but in 29.4% (5/17) of the corresponding normal tissue specimens ( P <0.05). CD44 was detected in 64.3% (36/56) of RCC tissue specimens but in 0 out of 17 normal tissue specimens ( P <0.001). Both ezrin and CD44 proteins were correlated with the histological grade and clinical stage of RCC ( P ＜0.05). In addition, ezrin in tumors >7.0 cm was significantly higher than that in tumors ≤7.0 cm ( P ＜0.05) whereas CD44 was not significantly different between tumors >7.0 cm and tumors ≤7.0 cm (P＞0.05). The rates of both ezrin- and CD44-positive staining were not significantly different between specimens collected from male and female patients ( P >0.05). Ezrin was positively correlated with CD44 in RCC ( r =0.427， P <0.01). Conclusion: Both ezrin and CD44 are positively correlated with the severity of renal cell carcinoma, indicating these two proteins may play an important part in the development and progression of RCC.
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Project Supported:
Project supported by the Science Foundation of Health Bureau of Hunan Province（No. B2013-095）
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