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Clinicopathological, diagnostic and prognostic significance of kallikrein 10 and vascular endothelial growth factor expression in ovarian carcinoma
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Abstract:
Objective: To evaluate the clinicopathological, diagnostic and prognostic signficance of kallikrein (KLK) 10 and vascular endothelial growth factor (VEGF) expression in ovarian carcinoma. Methods: Paraffin-embedded sections were prepared from 45 malignant, 10 benign and 12 borderline ovarian tumor tissue specimens collected from patients seeking care in the Department of Gynecology and Obstetrics of Nantong University-Affiliated Hospital between January 2004 and January 2009. Immunohistochemical staining was performed to detect KLK10 and VEGF proteins in these tissue sections. The correlation of KLK10 and VEGF protein levels with the clinicopathological features and prognosis of ovarian carcinoma were analysed. Results: Malignant ovarian tumor specimens, as compared with benign and borderline tumor specimens, had significantly higher percentages of KLK10-positive staining (86.7% vs 10.0%, 58.3%; P <0.05) and VEGF-positive staining (82.2% vs 20.0%, 41.7%, P <0.05). The proportion of KLK10-and VEGF-positive cells in the xxx tissue was significantly correlated with clinical stage, pathologic grade, lymphatic metastasis and 5-year survival rate ( P <0.05), but was independent of age, histological type, serum level of CA125, ascetic fluid or remnant tumor diameter ( P >0.05). The expression of KLK10 was positively correlated with the expression of VEGF ( r =0.5279, P =0.043). Conclusion: Both KLK10 and VEGF are highly expressed and positively correlated in ovarian carcinoma and thereby may serve as putative prognostic markers of the disease.
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