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Precision cancer immunotherapy: From theory to practice
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Abstract:
Precision medicine is a novel medical concept and medical model. Its benefits in the treatment of malignant tumors are being increasingly demonstrated in clinical settings. Precision immunotherapy is one of precision medicine strategies. In case of caner treatment, precision immunotherapy involves genetic screening of mutations, identification of the neo-antigen(s) capable of triggering strong immune responses using bioinformatics tools, screening and enrichment of the precision T cells for Neo-Antigen(s) (referred to as PNA-Ts), and amplification of the PNA-Ts in a large scale and transfusion of the PNA-Ts back into the autologous patients. Among the various existing treatment strategies for cancer patients, precision immunotherapy, by virtue of its unique advantages, is expected to become an important breakthrough in the treatment of cancer in China. This paper aims to outline the concept, features, processes, technical difficulties, etc. of precision cancer immunotherapy and compare the cons and pros of precision immunotherapy and chimeric antigen receptor T-cell immunotherapy. We will also discuss the opportunities and challenges of precision immunotherapy in the treatment of cancer, particularly in China.
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Project Supported:
Project supported by the National Key Science and Technology Program of China (No. 2013ZX09102-060, 2013ZX10002-010-007, 2012ZX0002-014-005)
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