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Immunoscore: A prognosis prediction tool based on the immunological characteristics of tumor region
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Abstract:
Cancer is a major and common public health problem worldwide. Effective prognostic indicators are beneficial in developing personalized therapeutic treatment specific to each individual case, preventing inappropriate and excessive therapies. At present, clinical predictions are primarily based on histopathological evaluations of the primary tumor tissues obtained during surgery, such as the TNM staging system. However, compiling evidence has emerged to suggest that patients in the same TNM stage may exhibit significantly distinct survival after surgery. Recently, scholars around the world have come to a consensus that immunoscore, as a means of statistically and pathologically quantitating the regional immune status around the tumor, may provide better predictions of the survival in colorectal cancer patients. As an important progress in tumor immunopathology, immunoscore provides the basis for determining the “pre-stored immunity” and suitability in receiving personalized immunotherapy in cancer patients. Herein, we will outline the development history and discuss prospective applications, and future directions of this promising prognostic indicator in oncology.
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Project Supported:
Project supported by the National Natural Science Foundation of China（No. 91029303，No. 31390433，No. 81302599），and the Central University Basal Research Foundation of China（No. WK2070000038）
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