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Immunoglobulin of non B cell origin promotes cancer initiation and progression
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Abstract:
Immunoglobulin (Ig), one of the most important immune molecules, has been considered to be produced only by B lymphocytes. The membrane bound Ig on B cells is responsible for the recognition of antigen, and the secreted Ig (antibody) exerts the immune defense effect via several mechanisms. This is the classic concept that can be found in the contemporary textbooks of immunology. However, in recent years, an emerging large body of evidence has confirmed that in addition to the B cell-derived Ig, there is another class of Ig which is of non-IB cell origin (non B-Igs). The non B-Igs are different from those of the classical Igs about their VHDJH or VκJκ rearrangement pattern, expression regulation and function. Observably, the non B-Igs are frequently over expressed in many cancer cells, and correlated with poor cell differentiation and patients’ prognosis. Importantly, the non B-Igs could promote growth of cancer cells, and play importent role in the mechanism of tumor progression. These findings suggest that the non B-Ig behaves like potential proto-oncogenes, which may be useful for tumor therapy as novel targets.
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Project Supported:
Project supported by the Key Project of National Natural Science Foundation of China（No. 39830410），the General Program of National Natural Science Foundation of China（No. 303071609，30572094，30772470，81272237），the Breeding Project of the Major Research Plan of National Natural Science Foundation of China（No. 91229102），and the Key Project of International Cooperation of National Natural Science Foundation of China（No. 81320108020）
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