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Archive > Volume 22 Issue 4 > 2015,22(4):484-488. DOI:10.3872/j.issn.1007-385X.2015.04.013 Prev Next
Clinical Research
The association of TMPRSS4 expression in early-stage non-small cell lung cancer tissues with tumor angiogenesis and its clinical significance
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Abstract:
Objective : To investigate the relationship between TMPRSS4 expression in early-stage non-small cell lung cancer and tumor angiogenesis and assess its clinical significance. Methods: Samples were collected from 87 NSCLC patients who had received surgical treatment in the Department of Thoracic Surgery of Qilu Hospital between January 2009 and January 2010. TMPRSS4 expression in cancerous, adjacent and normal tissues was assessed using immunohistochemical staining. Intratumoral microvessel density (MVD) was measured by counting immunostained CD34 positive endothelial cells. For Real-time PCR analysis, 14 matched pairs of tumor tissues and adjacent noncancerous tissues were collected from pulmonary lobectomy specimens of patients with NSCLC immediately after surgery in our department between September and October of 2014. Results: The level of TMPRSS4 mRNA in NSCLC tissues was significantly higher than that of the adjacent lung tissues（1.826±0.453 vs 0.829±0.366, P<0.05). The positive rates of TMPRSS4 in NSCLC tissues and adjacent tissues were significantly increased when compared with that in normal lung tissues（60.9%, 30.0% vs 167%，P<0.05). NSCLC tissues with high TMPRSS4 expression have significantly higher MVD than that of low TMPRSS4-expressing cancers (P<0.05). TMPRSS4 expression and MVD in cancerous tissues of T2 stage was significantly higher than that of T1 cancers（P<0.05). Conclusion: Increased TMPRSS4 expression is associated with high MVD in early-stage NSCLC tissue, and high TMPRSS4 expression and MVD in cancer tissue are closely related to the tumor infiltration depth. Thus, TMPRSS4 is a potential novel target for the treatment of patients with early NSCLC.
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Project Supported:
Project supported by the National Natural Science Foundation of China （No.30571844）, the Science and Technology Development Foundation of Shandong Province （No.2009GG10002007）, the Natural Science Foundation of Shandong Province （No.ZR2009CM090）, and the Wu Jie Ping Foundation （No.320.6750.12393）
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