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Archive > Volume 22 Issue 4 > 2015,22(4):489-494. DOI:10.3872/j.issn.1007-385X.2015.04.014 Prev Next
Clinical Research
Expression and clinical significance of transcription factor HSF1 in human esophageal squamous carcinoma
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Abstract:
Objective : To investigate the role of Heat-Shock Factor 1 (HSF1) in the development and progression of esophageal squamous cell carcinoma (ESCC). Methods: Cancerous (n=90）and adjacent (n=50) esophageal tissue specimens were collected from 90 patients with ESCC who were surgically treated in Qilu Hospital of Shandong University between January and December of 2009. Immunohistochemical staining was performed to assess the expression of HSF1 in carcinoma and adjacent tissues. Real-time PCR was used to determine the level of HSF1 mRNA in resected ESCC and adjacent tissues from 20 patients enrolled between September and November of 2014. 2 test was carried out to analyze the relationship between HSF1 expression and the clinical and pathological characters of these patients，Kaplan-Meier method was used to calculate their 5-year survival rates，Log-rank test was done to compare survival differences，and Cox regression analysis was utilized to determine the independent prognostic factors. Results: The expression of HSF1 at mRNA or protein levels were significantly elevated in ESCC tissues compared with that in adjacent esophageal tissues (P<0.01). Although it is not associated with the age (P=0.453), gender (P=0.692), smoking history (P=0.318) and drinking history (P=0.367) of these patients statistically, increased HSF1 expression is significantly related to the differentiation stages (P=0.012), lymph node metastasis (P=0.002), and TNM stages of the tumors (P=0.024). Univariate and multivariate analysis indicated that increased expression of HSF1 was associated with tumor relapse and prognosis. Conclusion: HSF1 is highly expressed in ESCC, and the elevated expression is associated with tumor progression and prognosis.
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Project Supported:
Project supported by the National Natural Science Foundation of China（No.30571844），the Natural Science Foundation of Shandong Province（No.ZR2013HM089），and the Wu Jie Ping Medical Foundation （No.320.6750.12393）
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