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Archive > Volume 22 Issue 5 > 2015,22(5):630-636. DOI:10.3872/j.issn.1007-385X.2015.05.014 Prev Next
Clinical Research
Expression and clinical significance of melanoma antigen-A9 and -A11 in esophageal squamous cell caricinoma tissues
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Abstract:
Objective:To investigate the expression of melanoma antigen (MAGE)-A9 and MAGE-A11 in esophageal squamous cell carcinomas in association with major clinical and biological variables. Methods: Cancerous (n=60）and adjacent (n=60) esophageal tissue specimens were collected from 60 patients with esophageal squamous cell carcinomas who underwent surgery in Hebei Medical University-Affiliated Fourth Hospital between September and November 2010. Testicular tissue specimens were collected from 5 prostate cancer patients in the same time as positive controls. MAGE-A9 and MAGE-A11 in these tissue specimens were assessed by immmuohistochemical staining. Correlations of MAGE-A9 and MAGE-A11 levels with patients' major clinical and demographic variables were determined. Results:MAGE-A9 and -A11 were positive in 45% (27/60) and 66.67% (40/60) of cancerous tissue specimens respectively but were both negative in tumor-adjacent tissue specimens. While MAGE-A9 protein was not correlated with age, clinical stage, tumor size, and lymph node metastasis(P>0.05), it was significantly correlated with the histological grade of the lesion in patients with esophageal squamous cell carcinoma (P<0.05). While MAGE-A11 protein was not correlated with age, histological grade, lymph node metastasis (P>0.05), it was significantly correlated with clinical stage and tumor size (P<0.05) in patients with esophageal squamous cell carcinoma. Log-rank test showed that the survival time was significantly shorter in MAGE-A9-positive (P=0.037) and MAGE-A11 positive (P=0.039) patients than in MAGE-A9-negative and MAGE-A11-negative patients. Cox multivariate analysis suggested that MAGE-A9 protein (P=0.026), MAGE-A11 protein (P=0.038), histological grade (P=0.026), TNM stage (P=0.008) and lymph node metastasis (P=0.010) were independent prognostic factors for overall survival. Conclusion: MAGE-A9 and -A11 are esophageal squamous cell carcinoma-specific antigens, thus having potential diagnostic and prognostic significance in clinical settings.
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Project Supported:
Project supported by the Financial Support Program of Hebei Province (No. \[2012\]2056), and the Science and Technology Support Program of Hebei Province(No. 14277732D)
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