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Archive > Volume 22 Issue 6 > 2015,22(6):747-753. DOI:10.3872/j.issn.1007-385X.2015.06.012 Prev Next
Clinical Research
Expression of S6K1 and 4EBP1 in colorectal cancer tissues and its association with clinicopathologic characteristics
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Abstract:
Objective:To investigate the expression of protein S6 kinase1（S6K1）and eukaryotic translation initiation factor 4E binding protein 1（4EBP1）in colorectal cancers and their relationship with clinicopathologic characteristics. Methods:The data of 100 patients diagnosed with colorectal cancer from January of 2007 to December of 2009 were collection from the General Hospital of Ji'nan Military Command of PLA. The specimens include 100 colorectal cancer tissues, 40 normal tissues of the incisional edges, 30 metastatic lymph nodes, and 15 distant metastasis cancer tissues. Immunohistochemical S-P method was used to examine the expression of S6K1 and 4EBP1 in these tissues. Results: The positive rates of S6K1 and 4EBP1 were 17.50% (7/40) and 22.50% (9/40) respectively in normal colorectal tissues, and they increased significantly to 74.00% (74/100) and 79.00% (79/100) in colorectal cancer tissues. The expression of 4EBP1 in colorectal cancer tissues was associated with its clinical stage and differentiation status (P<0.05). Patients with colorectal cancers expressing high levels of S6K1 and 4EBP1 had shorter progression free survival (PFS) (P<0.05), whereas S6K1 and 4EBP1 expression had no association with overall survival (OS) (P>0.05). Further analysis revealed that there was a direct correlation between the levels of S6K1 and 4EBP1 in colorectal cancer tissues (r=0.246, P<0.05). Conclusion:The expression of S6K1 and 4EBP1 are related to the development, progress, and prognosis of colorectal cancer. Therefore, they are potential therapeutic targets and informative prognostic biomarkers.
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