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Archive > Volume 22 Issue 6 > 2015,22(6):773-778. DOI:10.3872/j.issn.1007-385X.2015.06.016 Prev Next
Clinical Research
Expression of KISS1mRNA in peripheral blood and tumor tissues of patients with epithelial ovarian cancer and its clinical implication
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Abstract:
Objective : To investigate the expression of KISS1 in peripheral blood and carcinoma tissues of patients with epithelial ovarian cancer (EOC) and its clinical implication. Methods: RT-PCR was used to assess KISS1 mRNA level in ovarian tissues and peripheral blood of 40 patients with EOC, 20 patients with borderline epithelial ovarian tumors, 20 patients with epithelial benign tumors, and 20 patients with hysteromyoma. The differences of KISS1 expression among the 4 types of tissues and the relationship between KISS1 mRNA level and clinicopathologic features of EOC patients were further analyzed. Results: The level of KISS1 mRNA in carcinoma tissues and peripheral blood of patients with EOC was significantly higher than that in benign tumors and normal control group (P<0.001). The expression of KISS1 in cancer tissues and peripheral blood of patients with EOC was associated with the tumor grade, clinical stage, metastasis, and the size of post-operation residual tumor (P<0.05). The level of KISS1 mRNA in primary tumors of EOC was markedly elevated compared with that in the corresponding metastatic lesions (P=0.001). Furthermore, KISS1 expression in ovarian tissues was positively correlated to that in the peripheral blood（r=0.669，P<0.001）. Conclusion: KISS1 gene may be involved in the development and progress of EOC. Peripheral blood KISS1 mRNA may serve as a biomarker for the differentiation status , stage, recurrence, and metastasis of ovarian cancer.
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Project Supported:
Project supported by the Social Enterprise Technology Innovation and Demonstration Project of Nantong City (No.HS2013039）
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