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Archive > Volume 22 Issue 6 > 2015,22(6):779-784. DOI:10.3872/j.issn.1007-385X.2015.06.017 Prev Next
Clinical Research
The expression of p-mTOR and HIF-1α in colorectal cancer tissues and its clinical implication
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Abstract:
Objective:To examine the expression of phosphorylated mammalian target of rapamycin （p-mTOR） and hypoxia-inducible factor-1α(HIF-1α) in colorectal cancers and investigate its association with pathological features and prognosis.Methods：Surgical resected colorectal carcinoma and adjacent normal tissues were collected from patients with colorectal cancer enrolled into Jinan Military General Hospital from June, 2007 to December, 2013. Immunohistochemistry was performed to detect the expression of p-mTOR and HIF-1α in 63 cases of colorectal carcinoma tissues, 27 cases of metastatic lymph node tissues, and 12 cases of metastasized carcinoma tissues, with adjacent normal tissues as controls. χ2 test was used to analyze the relationship between p-mTOR and HIF-1α expression and clinical pathological features. Spearman correlation analysis was performed to analyze the association between p-mTOR and HIF-1α expression; Kaplan-Meier test was used for survival analysis related to p-mTOR and HIF-1α expression.Results: In colorectal carcinoma tissues, the positive rate of p-mTOR (50.80% vs 6.35%，P<0.01) and HIF-1α (65.08% vs 9.52%，P<0.01) was significantly higher than that of normal colorectal tissues. The expression of HIF-1α was correlated with distant metastasis，TNM stage and lymph node metastasis (P<0.05), and there was a positive correlation between p-mTOR and HIF-1α expression (r=0.345, P<0.01). Furthermore, the disease-free survival time and overall survival time of p-mTOR positive patients were significantly shorter than that of p-mTOR negative patients (P＜005). Conclusion: The expression of p-mTOR and HIF-1α are increased in colorectal cancer tissues, which are informative markers for clinical pathological staging and are useful prognosis factors.
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