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Archive > Volume 23 Issue 2 > 2016,23(2):267-275. DOI:10.3872/j.issn.1007-385X.2016.02.019 Prev Next
Clinical Research
Meta-analysis of relationship between high-expression of miR-17-92 cluster and prognosis of cancer patients
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Abstract:
Objective:Value of high-expression of miR-17-92 cluster in evaluating prognosis of cancer patients was analyzed with Meta-analysis. Methods: English literatures on the relationship of high-expression of miR-17-92 cluster and the prognosis of cancer patients were retrieved from Web of Science, PubMed and EMBASE from construction of the data bases to Oct 1, 2015. Key data were extracted from the literatures, pooled hazard ratios (HRs) and corresponding 95% confidence interval (CI) were calculated. Results: Total of thirty-nine literatures was included, involving 4 908 patients. The high-expression of miR-17-92 cluster was associated with low overall survival rate of the patients with malignant tumor (HR=1.83, 95% CI: 1.58~2.12, P=0.000). Furthermore, disease-free survival rate (HR=1.80, 95% CI: 1.43~2.26, P=0.000), progression-free survival rate (HR=1.83, 95%CI: 1.11~3.02, P=0.018) and cancer-specific survival rate (HR=1.59, 95%CI: 1.04~2.42, P=0.032) in the cancer patients with high-expression of miR-17-92 cluster were all reduced. However, the pooled HRs for relapse- free survival rate was not statistically significant (P=0539). Conclusion: The high-expression of miR-17-92 cluster was associated with poor prognosis of the patients with malignant tumor, and it could be expected as a new marker for prognosis of the cancer patients.
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Project Supported:
Project supported by the National Natural Science Foundation of China(No. 81273814), and the Key Specific Project Foundation of Science and Technology about Development of New Medicine of Guangdong Province (No.2013A022100031)
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