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Archive > Volume 23 Issue 3 > 2016,23(3):387-391. DOI:10.3872/j.issn.1007-385X.2016.03.016 Prev Next
Clinical Research
Non-small cell lung cancer with brain metastasis harbored more mutant EGFR gene
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Abstract:
Objective:To evaluate the relationship between epidermal growth factor receptor（EGFR） mutations and brain metastasis（BM）in non-small cell lung cancer（NSCLC）. Methods： 90 cases of patients who were pathologically diagnosed as NSCLC in the department of thoracic surgery and oncology of Huashan Hospital, Fudan University, from January 1, 2008 to October 31, 2013 were selected in this study, and we collected the lung cancer tissues. Among them, 30 patients with brain metastasis (BM) were assigned in observation group, and the rest 60 patients with no brain metastasis (NBM) were assigned in control group. The EGFR mutation status was detected by direct sequencing. Results: The patients with BM had more EGFR mutations than the patients with NBMs (46.7% vs 15.0%, P＜0.05), no matter in adenocarcinoma or squamous carcinoma. Conclusion: EGFR mutations increasing may be associated with BM in NSCLC.
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Project Supported:
Projects supported by the National Natural Science Foundation of China（No. 81302010，No. 81101551），and the Natural Science Foundation from Committee of Science and Technology of Shanghai（No. 13ZR1405000）
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