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Archive > Volume 23 Issue 3 > 2016,23(3):397-402. DOI:10.3872/j.issn.1007-385X.2016.03.018 Prev Next
Clinical Research
Clinical effects and safety of chemotherapy combined with DC-CIK in treatment of colon cancer patients after complete mesocolic excision
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Abstract:
Objective:To evaluate the safety and clinical effects of chemotherapy combined with dendritic cells and cytokine-induced killer cells (DC-CIKs) in the treatment of colon cancer patients after complete mesocolic excision (CME). Methods: The present study enrolled 82 patients with colon cancer (stageⅢ) who underwent CME in the Department of Surgery, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine of Hebei Province between June 2012 and December 2013. The patients were randomly divided into chemotherapy group and combined therapeutic group. Chemotherapy group consisted of 42 cases, who received 6 cycles of chemotherapy with the protocol of CapeOX. Combined therapeutic group consisted of 40 cases, who were given DC loaded with autologous tumor antigen and autologous CIK cells, in addition to the same chemotherapeutical protocol. The changes in carcino-embryonic antigen (CEA), cellular immune indicators (percentage of CD3+, CD4+, CD8+, CD19+, CD56+, and CD4+ CD25+ FOXP3+ Treg in peripheral blood) and side effects of drugs were recorded, and the 2-year recurrence rate of both groups were compared. Results:The values of CEA decreased significantly at 2 weeks after the procedures in both groups (P<0.05). There were no differences in the values of CEA before and after the treatment as well as 1 year after surgery in both groups (P>0.05). The values of CEA at 2 years after surgery in chemotherapy group were notably higher than those of post-treatment and those of combined therapeutic group (both P<0.05). The proportion of CD8+ and Tregs was reduced significantly after the treatment in chemotherapy group (P<0.05), and other indicators showed no significant differences. The proportion of CD3+, CD4+, CD8+, CD19+ and CD3+CD56+ was increased markedly (P<0.05), whereas the proportion of Tregs was reduced significantly after the treatment in the combined therapeutic group (P<0.05). Fewer side effects (including bone marrow suppression, nausea and vomiting, diarrhea, peripheral nerve toxicity and hand-foot syndrome) were observed in the combined therapeutic group, as compared with the chemotherapy group (all P<0.05). The 2-year recurrence rates in the chemotherapy group and the combined therapeutic group were 23.81% and 7.5%, respectively, with significant difference between two groups (P<0.05). Conclusion: Sequential DC injection and autologous CIK cells transfusion combined with chemotherapy may improve the therapeutic effect in colon cancer patients with CME surgery by enhancing the autoimmune function. Therefore, it can improve the life quality, reduce side effects caused by drugs and more importantly, reduce the 2-year recurrence rate.
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Project Supported:
Project supported by the Science and Technology Foundation for Youths from Health Department of Hebei Provine（No.1020140135），and the Science and Technology Support Project of Cangzhou City（No. 131302194）
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