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Archive > Volume 23 Issue 5 > 2016,23(5):601-608. DOI:10.3872/j.issn.1007-385X.2016.05.003 Prev Next
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Research progresses of circulating tumor DNA
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Abstract:
Circulating tumor DNAs (ctDNAs) are small genomic fragments released by tumor cells into circulatory system, which come from all of tumor bearing parts of the patients, have characters of extremely low content, great difference among the patients, a short half-time, homogeneous and carrying tumor-specific genetics and epigenetic mutations, and so on, are closely related to development, evolution, dormancy, drug resistance, metastasis and recurrence of the tumor and are gradually becoming key approach in molecular research field of oncology. At present, there is a wide variety of detection methods and platforms for ctDNA, which are mainly divided into PCR-based assay and next-generation sequencing (NGS) , each of both them has their own advantages and disadvantages, and need to be flexibly selected according to research objective, and uniform standards should be established. ctDNA could become as an ideal hematogenous biomarker for tumor screening, early diagnosis, individually therapy and prognostic assessment with development of related techniques and continuous improvement of laws and regulations. This paper reviewed research progresses of ctDNA in the field of oncology.
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Project Supported:
Project supported by the International Science & Technology Cooperation Program of China (No. 2014DFA33010)，and the Clinical Ancillary Departments Capacity Building Project of Hospital Development Center of Shanghai (No. SHDC22014011)
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