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Archive > Volume 23 Issue 5 > 2016,23(5):670-674. DOI:10.3872/j.issn.1007-385X.2016.05.014 Prev Next
Clinical Research
Peripheral blood sCTLA-4: prognostic factor of patients with advanced non-small cell lung cancer
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Abstract:
Objective:To explore the relationship between soluble cytotoxic T lymphocyte associated antigen-4 (sCTLA-4) and the survival time of advanced NSCLC patients by examine its expressions in peripheral blood of patients. Methods: The research collected the peripheral blood of 58 advanced NSCLC patients confirmed by oncology department of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from August 2010 to June 2013, and also collected the peripheral blood from 30 healthy persons during the same time period. Researcher used ELISA to test the sCTLA-4 content in the blood, and obtained the data of survival time through telephone follow-up or collected from Shanghai Municipal Center for Disease Control and Prevention, to analyze the relationship between sCTLA-4 and survival time. Results: The sCTLA-4 in peripheral blood of NSCLC patients was higher than that of healthy people (70.7% vs 6.7%， χ2=32.44，P<001); the median survival time of the patients with over-expressed sCTLA-4 was shorter (41.63 months vs 31. 57 months, χ2=7.77，P<0.01) than those patients with low expression, indicating a higher death risk （RR=305， χ2=8.01, P<0.01). Conclusion: sCTLA-4 was highly expressed in the peripheral blood of advanced NSCLC patients, and it could be used as one of the prognostic factors for patients with advanced NSCLC.
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Project Supported:
Project supported by the National Natural Science Foundation of China(No.81173224, No.81373621),Science and Technology Commission of Shanghai Municipality(No.13401905100),and Longhua Medical Team of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine(D-11)
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