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Archive > Volume 23 Issue 5 > 2016,23(5):698-702. DOI:10.3872/j.issn.1007-385X.2016.05.019 Prev Next
Clinical Research
Clinical characteristics and treatment analysis of advanced lacrimal gland carcinoma
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Abstract:
Objective:Advanced lacrimal gland carcinomais rare andthere is rate and there is no standard treatment regimen. To analyze the clinical presentation and treatment of advanced lacrimal gland carcinoma, in order to improve the understanding of this rare disease. Methods: Six patients with advanced lacrimal gland carcinoma were treated in our hospital between October 2007 and March 2016. The clinical and follow-up data were analyzed retrospectively. Results: All the patients were male (33-66 years old), including four cases of moderately or poorly differentiated adenocarcinoma and two cases of adenoid cystic carcinoma. The averagelongest diameter of lacrimal gland tumorwas (3.3±0.5) cm, and in four cases the tumor infiltrated the bone of orbital wall. After complete resection of lacrimal gland lesions, distant metastasis appeard in all 6 cases. Bone metastasis was observed in five cases, lung in four,distant lymph node in 2, and skin and liver in 1 case, respectively. Chemotherapy was documented in 6 patients, from whom 5 received cisplantin plus paclitaxel regimen as the first-line chemotherapy and partial response was observed in 1, stable disease in 2 and progression disease in 3. One patient failed threelines of chemotherapy regimens was treated with apatinib as the fourth line therapy and achieved a partial response with a progression-free survival of 6.1 months. The adverse events related with apatinib were hand-foot syndrome, hypertension, diarrheaand hemoptysis, which were all manageable. Conclusion: Poor differentiation and wide local invasion are the risk factors for distant metastases in lachrymal gland carcinoma patients. Bone and lung were common sites of metastases. For patients with metastatic disease, chemotherapy has a limited role, but apatinib may represent an effective therapeutic option and deserves further study.
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