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Archive > Volume 23 Issue 6 > 2016,23(6):830-834. DOI:10.3872/j.issn.1007-385X.2016.06.016 Prev Next
Clinical Research
Clinical efficacy of autologous CIK cell combined with radiotherapy and chemotherapy for intermediate-advanced cervical cancer
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Abstract:
Objective:To explore clinical efficacy of autologous CIK cell combined radiotherapy and chemotherapy for intermediate-advanced cervical cancer. Methods: In the randomized and controlled trial, 89 patients with intermediated-advanced cervical cancer, who were hospitalized in the center of tumor Diagnosis and Treatment, Kaifeng Center Hospital during October 2010 to July 2015, were divided into treatment group (44 cases for CIK cell combined radiatherapy and chemotherapy) and control group (45 cases for radiatherapy and chemotherapy alone) acording to ratio of 1∶1. Effective rates, survival periods, immunofunctions and qualities of life of the patients in the two groups were compared and analyzed. Results: Total effective rate of the patients in the treatment group was 88.64%, which was obviously higher than 68.89% in the control group (P<0.05). Survival rates for 1, 2 and 3 years in the treatment group were 93.18%, 72.27% and 4773% respectively, which were higher than 88.88%, 68.89% and 42.22% in the control group, but the differences were not statistically significant (P>0.05). Comparing with pre-treatment, peripheral blood CD3+ and CD4+/CD8+ of the patients in the treatment group at post-treatment significantly increased (P<0.05), and peripheral blood CD3+ and CD4+/CD8+ of the patients in the contol group at post-treatment significantly decreased (P<0.05). In the treatment group, as comparing post-treatment 25th day (T25) with pre-treatment 1st day (B1) only one item feeling had significant difference (t=2.0976, P<0.05), however in the contol group as comparing T25 with B1, body, role, social and holistic health had obvious differences (t=3.3463, 3.4080, 2.3402 and 3.3010. P<0.05 and 001). Comparison between the two groups at T25, body, social and holistic health had significant differences (t=28262, 2.5797 and 19923, P<0.05 and 0.01). Conclusion: Short-term efficacy of CIK cell combined radiotherapy and chemotherapy for the patients with intermediate-advanced cervical cancer might be better than that of radiotherapy and chemotherapy alone, which could obviously enhance immunofunction and improve life quality of the patients, but the benefit of prolonging the survival period of the patients has not yet been seen.
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Project Supported:
Project supported by the Science and Technology Research Projects of Kaifeng City （No.130324）
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