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Archive > Volume 23 Issue 6 > 2016,23(6):835-839. DOI:10.3872/j.issn.1007-385X.2016.06.017 Prev Next
Clinical Research
Relationship between polymorphism of ATF5 gene and genetic susceptibility to hepatocellular carcinoma in Zhuang population of Fusui County, Guangxi Zhuang Autonomous Region
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Abstract:
Objective: To explore relationship between polymorphism of rs283526 and rs8647 loci in ATF5 gene and genetic susceptibility of hepatocellular carcinoma (HCC) in Zhuang population of Fusui County, Guangxi Zhuang Autonomous Region. Methods: With case-control study, 79 cases of HCC family (observation group) and 40 cases of normal family (control group) in Zhuang population were selected from Fusui Country of Guangxi Zhuang Autonomous Region, mass spectrometry assay was used to examine distribution frequency of rs283526 and rs8647 loci in ATF5 gene among them. Correlation between various genotypes and onset risk of HCC were analyzed by unconditional Logistic regression method. Results: In population of the control group, HCC onset risks of individuals with rs283526 locus CT, TT genotype of ATF5 gene were 0.181 times (P<0.05) and 0.348 times (P<0.05) of individuals with CC genotype respectively, HCC onset risk of individuals with rs283526 locus T allele genotype was 0.405 times (P<0.01) of individuals with C allele genotype. In control population with rs8647 locus of ATF5 gene, HCC onset risks of individuals with GA, AA genotype were 1.022 times and 1.949 times, HCC onset risk of individuals with rs8647 A allele genotype was 0.925 times of individuals with G allele genotype, but all the differences were not statistically significant (P>0.05). Conclusion: There could be correlation between polymorphism of rs283526 locus of ATF5 gene and genetic susceptibility of HCC in Fusui Country of Guangxi Zhuang Autonomous Region, T allele genotype of ATF5 gene might be a protective factor of HCC.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No. 81260320)
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