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Archive > Volume 24 Issue 3 > 2017,24(3):215-221. DOI:10.3872/j.issn.1007-385X.2017.03.001 Prev Next
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Progresses of research on mechanism of intestinal flora intervening the negative immune regulation of tumor
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Abstract:
Intestinal flora not only play an important role in human nutrition metabolism and immune homeostasis, but also was closely related with progress of malignant tumor. In recent years, intestinal flora tacking part in immune regulation of tumor has drawn much attention from researchers. Recent researches found that intestinal flora affects tumorigenesis and development of tumor via intervening negative immune regulatory network. However, most of researches on relationship between intestinal flora and immune regulation of tumor remained in correlation analysis, its molecular mechanism has not been completely elucidated. The paper expounded novel progresses of research on intestinal flora regulating mechanism of negative immune regulation and intervening malignant tumor progression from four aspects which were negative immune regulatory cells, negative immune regulatory molecules, negative immune regulatory cytokines and combined action of the multiple factors, and expected to provide new ideals and strategies for the tumor therapy.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No.U1502222，No.81470005，No.81260307), the Applied Basic Research Program of Science and Technology Department of Yunnan Province（No.2015FB074，No.2014FB065，No.2014FB064）， and the Graduate Students Program of Scientific Research Foundation of Education Department of Yunnan Province (No.2016YJS057)
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