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Archive > Volume 24 Issue 3 > 2017,24(3):253-258. DOI:10.3872/j.issn.1007-385X.2017.03.007 Prev Next
Clinical Research
Curative effect of the 1st line and the 2nd line therapies for the 232 patients with advanced mucosal melanoma and factors efecting prognosis of the patients
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Abstract:
Objective:To explore clinical features of the patients with advanced mucosal melanoma (MM) and effect factors on therapy and prognosis of the patients. Methods: Clinical data and regimens for the 1st line and the 2nd line therapies of 232 patients with advanced MM who were hospitalized in Department of Renal Cancer and Melanoma, Peking University Cancer Hospital during January 2008 to December 2015 were collected. Survival status of the patients were followed up, and multiple factors that effect on overall survival and prognosis of the patients were statistically analyzed. Results:There were 232 patients with advanced MM in this study (101 male, 131 female). Median age of the patients was 56 years old; anatomic sites of the primary melanoma were anorectum (29.3%), nasal cavity (25.0%), urogenital tract (20.7%), oral cavity (20.3%), esophagus (4.7%), M staging at visiting time of the patients were 17.2% as M1a, 21.6% as M1b, 61.2% as M1c; Most patients had multiple metastases, most common metastic sites of the primary melanoma were lung (504%), liver (34.9%), bone (23.3%); median progression free survival (mPFS) was 4.5 months in the patients received the 1st line therapy and 2.5 months in the patients received the 2nd line therapy; overall survival (OS) was 110 months in all of the patients, and among them, OS was 16.0 months in the patients as M1a stage, 14.0 months in the patients as M1b stage, 10.0 months in the patients as M1c stage. Prognosis analysis found that OS was significantly correlated with M staging at visiting time and serum lactate dehydrogenase (LDH) (P<0.01) and did not obviously correlated with anatomic sites of the primary melanoma, gender, age, gene mutation status of the patients. Conclusion: Nasal and oral cavities could be predilection sites of the MM. M staging at the visiting time of the patients and the serum LDH level could be dependent prognosis factor of OS.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No. 81603038), the Grants From Beijing Talents Fund (No. 2016000021469G186), and the Beijing Municipal Administration of Hospitals Incubating Program (No. PX2017042)
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